Lupus was a horrific disease and one of the worst things to ever happen to Michael.

IhateTheMedia

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He had to deal with all of this, combined with a pre-existing eating disorder, insomnia from touring. What's worse is that According to the Lupus Foundation of America, emotional stress can trigger lupus flares. It is one of many possible triggers, including infections, ultraviolet light, and exhaustion. So whenever he was being lynched by the media, false accusations, or fighting with his record companies etc, it likely significantly increased the likelyhood of him having a flair-up. This disease was like the main cause of most of his suffering i think.
 
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