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Propofol: A Dangerous Kind of Rest

kasume

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Tung: In the second experiment, we sleep deprived a rat and looked at the recovery from sleep deprivation. Normally when a rat is sleep deprived, it shows a rebound increase, a transient increase in sleep for a while as they sort of discharge their sleep need or sleep debt.

(Rats in this study were deprived of sleep for 24 hours by being placed on a platform above a pan of water. Whenever rats begin to sleep, the platform rotates, forcing them to wake up and walk to avoid splashing down in the water)

So we then allowed rats to sleep naturally or gave them a period of sedation with propofol and looked to see how they recover. What we found is that recovery in rats given propofol occurred as quickly as recovery in rats allowed to sleep normally. We concluded that, at least in rats, subjects can discharge their sleep debt under propofol sedation to the same degree as they are able to do it using naturally occurring sleep.

Q: But does that mean that propofol sedation is the same as sleep?

Tung: Propofol sedation is nothing at all like sleep. Sleep is reversible with external stimulation - if you shake somebody, they wake up. Propofol is obviously not like that. Sleep shows a characteristic pattern of EEG behavior, while propofol does not. (For instance, Tung explains, cyclical patterns of REM and nonREM sleep are not observed during propofol sedation, in rats or humans) Sleep, in general, preserves blood pressure and the ability to breathe and propofol does not. They are very different states.

Q: All of your propofol research has been in rats, has there been any research done in humans along these lines?

Tung: No, there has not. It does appear that humans given propofol for prolonged periods do not appear to be sleep deprived when you turn off the drug. No data exist to support the specific use that has been alleged in the Michael Jackson case (using propofol as a treatment for insomnia),. Use to facilitate regular sleep is not at all safe. The benefit is way outstripped by the risk…if there is any benefit.

Nobody is advocating its use outside a hospital for patients that are not critically ill. That is outside the boundaries of currently accepted care.

full article
http://sciencelife.uchospitals.edu/2009/07/31/propofol-a-dangerous-kind-of-rest/
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That would mean that Michael cannot dream, because we dream in our REM sleep. I wonder if anyone knows of a dream Michael told them he had during those six weeks.
 
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What should I watch for while taking propofol?
You will be closely monitored following administration of propofol.
Another thing I have to share about propofol.

Propofol is a very short-acting drug, and its effects generally wear off in just a few hours. However, propofol may affect your ability to drive or operate machinery for several hours after use. Do not attempt to drive yourself home if you have received propofol for minor outpatient surgery or diagnostic tests.

Avoid alcohol, mood-altering drugs, or any other medicines for at least 24 hours after a dose of propofol, unless approved by your prescriber or health care professional.

http://www.drugs.com/propofol.html
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It seems reasonable to assume that a “normal” cognitive performance is a prerequisite for optimal performance of some tasks of everyday life, including the ability to drive and the ability to operate machinery. Furthermore, “normal” performance of cognitive functioning may well be associated with other aspects of “quality of life” such as tasks demanding vigilance, ability to concentrate, motivation, attention, and intact memory.
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In TII, Michael looked very attentive and aware, even concentrated on the slightest detail of his music.
 
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what a strange way to find out all the people coming out of the woodwork who knew who Michael Jackson was. though the media would have people think otherwise.
 
Now, the funny thing is that I have read both accounts- people supposedly having dreams and then accounts that state, that nope, absolutely no way does anybody deeply anesthetized dream.

Having experienced Propofol, I don't recall a dream in my personal experience.

In cases of insufficient anesthesia people recall remembering conversations that took place etc- which can lead to severe trauma- not hard to imagine.
 
kasume said:
That would mean that Michael cannot dream, because we dream in our REM sleep. I wonder if anyone knows of a dream Michael told them he had during those six weeks.
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another point is Michael would not be able to breath on his own which negates the fact, "he gave the drug to himself".:(
 
Propofol doesnt give you ANY kind of rest at all. So there was no reason period for Michael to be taking this. No REM, nothing. The second you stop getting propofol, the second you wake up.
 
you can breath with propofol. its more how deep they want you in so how deeper how more you can not breath. i know this for a fact, a was under propofol for a thing and i was not intubated, and while once again another time a was intubated because they gave more. so it depends
 
Using propofol for sleep makes absolutely no sense to me. As everyone has already stated it's not sleep you're getting...so regardless of what the nurse stated, I think it's a possibility that it was used for his pain issues after rehearsing as it would "knock you out", so you wouldn't feel a thing. There were no painkillers in his body at time of death. So perhaps that was his "substitute" as it is not addictive at all and painkillers are quite addictive...(also was used during HIStory Tour, Munich Germany...for back pain?) The irony of all of this is that he is being labeled an "addict" by many who seem not to have a clue unfortunately. I know he would have been in pain after rehearsing for how many hours? I don't think there is any doubt about that. He never did anything half-ass. Still a very dangerous drug to use, since propofol is a respiratory depressant and anyone using it needs to be watching their patient every nanosecond they are under it.

Saying all that, one still has to deal with motive and agendas of said Dr and why he chose to risk it if he were a legit medical professional. I don't buy he didn't know the risk. He wasn't an intern. Why a cardiologist instead of an anesthesiologist? Michael did ask the nurse for the latter, it's stated in her Greta Van Susteren interview...so why Murray?
 
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