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What are the effects of propofol daily?

Anesthesia/MAC Sedation
ICU Sedation



Body as a Whole:
Asthenia, Awareness, Chest Pain,
Extremities Pain, Fever, Increased
Drug Effect, Neck Rigidity/Stiffness,
Trunk Pain
Fever, Sepsis, Trunk Pain, Whole Body Weakness



Cardiovascular:
Arrhythmia, Atrial Fibrillation,
Atrioventricular Heart Block,
Bigeminy, Bleeding, Bundle Branch
Block, Cardiac Arrest, ECG Abnormal, Edema,
Extrasystole, Heart Block,
Hypertension, Myocardial
Infarction, Myocardial Ischemia,
Premature Ventricular Contractions,
ST Segment Depression,
Supraventricular Tachycardia,
Tachycardia, Ventricular Fibrillation
Arrhythmia, Atrial Fibrillation, Bigeminy, Cardiac
Arrest, Extrasystole, Right Heart Failure, Ventricular
Tachycardia



Central Nervous System:
Abnormal Dreams, Agitation,
Amorous Behavior, Anxiety,
Bucking/Jerking/Thrashing,
Chills/Shivering/Clonic/Myoclonic
Movement, Combativeness,
Confusion, Delirium, Depression,
Dizziness, Emotional Lability,
Euphoria, Fatigue, Hallucinations,
Headache, Hypotonia, Hysteria,
Insomnia, Moaning, Neuropathy,
Opisthotonos, Rigidity, Seizures,
Somnolence, Tremor, Twitching
Chills/Shivering, Intracranial Hypertension,
Seizures, Somnolence, Thinking Abnormal



Digestive:
Cramping, Diarrhea, Dry Mouth,
Enlarged Parotid, Nausea, Swallowing,
Vomiting
Ileus, Liver Function Abnormal



Hematologic/Lymphatic:
Coagulation Disorder, Leukocytosis




Injection Site:
Hives/Itching, Phlebitis,
Redness/Discoloration




Metabolic/Nutritional:
Hyperkalemia, Hyperlipemia
BUN Increased, Creatinine Increased, Dehydration,
Hyperglycemia, Metabolic Acidosis, Osmolality
Increased



Respiratory:
Bronchospasm, Burning in Throat,
Cough, Dyspnea, Hiccough,
Hyperventilation, Hypoventilation,
Hypoxia, Laryngospasm, Pharyngitis,
Sneezing, Tachypnea, Upper Airway
Obstruction
Hypoxia



Skin and Appendages:
Conjunctival Hyperemia, Diaphoresis,
Urticaria
Rash



Special Senses:
Diplopia, Ear Pain, Eye Pain,
Nystagmus, Taste Perversion,
Tinnitus




Urogenital:
Oliguria, Urine Retention
Kidney Failure
http://www.drugs.com/pro/propofol.html


I found this to be interesting...look at where it talks about how propofol effects your central nervous system....the chills??? That makes me think about when Michael placed that call to Nurse Lee. It is so obvious that Michael had his reservations about using this stuff and he probably by that point didn't trust Murray anymore.. Its so depressing....all they had to do was take Michael to the hospital when he said he wanted to go..he would still be here.
 
xthunderx2 said:
Anesthesia/MAC Sedation
ICU Sedation



Body as a Whole:
Asthenia, Awareness, Chest Pain,
Extremities Pain, Fever, Increased
Drug Effect, Neck Rigidity/Stiffness,
Trunk Pain
Fever, Sepsis, Trunk Pain, Whole Body Weakness



Cardiovascular:
Arrhythmia, Atrial Fibrillation,
Atrioventricular Heart Block,
Bigeminy, Bleeding, Bundle Branch
Block, Cardiac Arrest, ECG Abnormal, Edema,
Extrasystole, Heart Block,
Hypertension, Myocardial
Infarction, Myocardial Ischemia,
Premature Ventricular Contractions,
ST Segment Depression,
Supraventricular Tachycardia,
Tachycardia, Ventricular Fibrillation
Arrhythmia, Atrial Fibrillation, Bigeminy, Cardiac
Arrest, Extrasystole, Right Heart Failure, Ventricular
Tachycardia



Central Nervous System:
Abnormal Dreams, Agitation,
Amorous Behavior, Anxiety,
Bucking/Jerking/Thrashing,
Chills/Shivering/Clonic/Myoclonic
Movement, Combativeness,
Confusion, Delirium, Depression,
Dizziness, Emotional Lability,
Euphoria, Fatigue, Hallucinations,
Headache, Hypotonia, Hysteria,
Insomnia, Moaning, Neuropathy,
Opisthotonos, Rigidity, Seizures,
Somnolence, Tremor, Twitching
Chills/Shivering, Intracranial Hypertension,
Seizures, Somnolence, Thinking Abnormal



Digestive:
Cramping, Diarrhea, Dry Mouth,
Enlarged Parotid, Nausea, Swallowing,
Vomiting
Ileus, Liver Function Abnormal



Hematologic/Lymphatic:
Coagulation Disorder, Leukocytosis




Injection Site:
Hives/Itching, Phlebitis,
Redness/Discoloration




Metabolic/Nutritional:
Hyperkalemia, Hyperlipemia
BUN Increased, Creatinine Increased, Dehydration,
Hyperglycemia, Metabolic Acidosis, Osmolality
Increased



Respiratory:
Bronchospasm, Burning in Throat,
Cough, Dyspnea, Hiccough,
Hyperventilation, Hypoventilation,
Hypoxia, Laryngospasm, Pharyngitis,
Sneezing, Tachypnea, Upper Airway
Obstruction
Hypoxia



Skin and Appendages:
Conjunctival Hyperemia, Diaphoresis,
Urticaria
Rash



Special Senses:
Diplopia, Ear Pain, Eye Pain,
Nystagmus, Taste Perversion,
Tinnitus




Urogenital:
Oliguria, Urine Retention
Kidney Failure
http://www.drugs.com/pro/propofol.html


I found this to be interesting...look at where it talks about how propofol effects your central nervous system....the chills??? That makes me think about when Michael placed that call to Nurse Lee. It is so obvious that Michael had his reservations about using this stuff and he probably by that point didn't trust Murray anymore.. Its so depressing....all they had to do was take Michael to the hospital when he said he wanted to go..he would still be here.
Click to expand...



why didn't he go to the hospital? do we even know who spoke to Nurse Lee? was it Michael Amir? why didn't Amir take MJ to the hospital? it was obvious to me that Murray didn't know what the hell he was doing and he was obviously making MJ sick. Did anyone not notice that MJ was fine in March and started to get sick when Murray started his 'treatments'?? Wouldn't common sense tell you that Murray was making MJ sick with his 'treatments? Why didn't anyone help Michael??
 
This is only conjecture, but I think nobody took him to the hospital because that would have revealed that Murray was giving him propofol. (Michael would have TOLD them? I'm sure he didn't want to DIE!) Looking at the list of side-effects above (and in reference to the topic of the thread), it seems VERY likely that the neurological symptoms he described were due to the propofol.

Don't know who talked to Lee. Sure, it would be common sense that Murray was making Michael sick. Somebody should have taken him to the HOSPITAL! But then Murray's "treatments" would have been revealed; Murray would have no doubt been fired, and would not have gone to London. So maybe Murray gave instructions NOT to take Michael to any hospital? Michael did not deserve to die. . .
 
Urogenital:
Oliguria, Urine Retention
Click to expand...
wonder how long mj had been taking flomax for? i know he had an enlarged prostate but thats another coincedence that u can suffer from urine retention
 
This is only conjecture, but I think nobody took him to the hospital because that would have revealed that Murray was giving him propofol. (
Click to expand...
propfol wouldnot be detected anywhere in his blood after 30 minutes maximum, and i would have disppeared from his system completley within hours . I don't believe they would have discovered any propofol, Murray was afraid of the other things he was giving to be exposed by mj.

wonder how long mj had been taking flomax for? i know he had an enlarged prostate but thats another coincedence that u can suffer from urine retention
__________________
Click to expand...

flomax was prescribed on the third of June 2009 by Murray himself, so yeah you probably right about that
 
Soundmind said:
propfol wouldnot be detected anywhere in his blood after 30 minutes maximum, and i would have disppeared from his system completley within hours . I don't believe they would have discovered any propofol, Murray was afraid of the other things he was giving to be exposed by mj.



flomax was prescribed on the third of June 2009 by Murray himself, so yeah you probably right about that
Click to expand...

I honestly believe that's why Murray waited as long as he did to call 911.. He was hoping like hell that the propofol would've disappeared from MJ's system. That's why he never mentioned it to the ER staff or to the ER doctor
 
I find it very strange that an exact time of death is uknown. How is that possible ?!
There are ways to measure it almost exactly, right ?
I read somewhere before that the room was heated and extremely warm eventhough it was summer. What about that ?
 
ive asked that from many doctors and those who work in a drug store (actually anyone i met or confronted in my country, Iran) anytime i ask it, they go... what? propofol for insomnia? that's for surgery in hospitals and not even in ER.
none had heard anyone doing that and i did not mention Him.


and they get more shocked when i say "HOW ABOUT AT HOME"

"it's not to be used at home" I've heard that over and over.
 
ForeverBeInPeaceMichael said:
ive asked that from many doctors and those who work in a drug store (actually anyone i met or confronted in my country, Iran) anytime i ask it, they go... what? propofol for insomnia? that's for surgery in hospitals and not even in ER.
none had heard anyone doing that and i did not mention Him.


and they get more shocked when i say "HOW ABOUT AT HOME"

"it's not to be used at home" I've heard that over and over.
Click to expand...

and they're right.. Murray knew it too that's why he never told the EMT or the ER doctor what he gave MJ. The ER medical team would've been absolutely floored and shocked
 
StacyJ said:
and they're right.. Murray knew it too that's why he never told the EMT or the ER doctor what he gave MJ. The ER medical team would've been absolutely floored and shocked
Click to expand...
of course he was aware of everything, that lying scumbag
 
Murray's team has said that Murray took all of the proper precautions. I am still trying to find out what precautions did Murray take? I have yet to hear of any precautionary measures he took
 
zpredra5 said:
I find it very strange that an exact time of death is uknown. How is that possible ?!
There are ways to measure it almost exactly, right ?
I read somewhere before that the room was heated and extremely warm eventhough it was summer. What about that ?
Click to expand...

I find that odd too. and the fact that Murray has no idea when his patient died demonstrates he wasn't watching him at all
 
StacyJ said:
Murray's team has said that Murray took all of the proper precautions. I am still trying to find out what precautions did Murray take? I have yet to hear of any precautionary measures he took
Click to expand...

If we accept the Ratner story as true (which I think we probably have to, propofol was specifically mentioned and it was in 2000/1 - so too coincidental that they would name the same drug as 9 years later) - the precautions taken during HIStory tour were way more appropriate ie full crash cart, another doctor present. Murray just seemed to hook MJ up by IV and then think the whole system would take care of itself :bugeyed
 
if the whole ratner story from the history tour is true. it only helps murrays defence if ratner says he bullied me into giving it to him etc etc. so ratner takes the stand and says mj had terrible insomnia i was trying to help him. he wanted to sleep and this was seen as the only option becasue of the shows. it doesnt hurt mj one bit.

I find it very strange that an exact time of death is uknown. How is that possible ?!
There are ways to measure it almost exactly, right ?
Click to expand...
not really. i would think its pretty impossible to get an exact time unless the circumstances support it. generally i would think u would be looking at a TOD within so many hours. look at the medics they said within 20 mins and 1 hr when they got there. they may have a rough idea but i doubt u could ever prove it down to a certain time
 
elusive moonwalker said:
if the whole ratner story from the history tour is true. it only helps murrays defence if ratner says he bullied me into giving it to him etc etc. so ratner takes the stand and says mj had terrible insomnia i was trying to help him. he wanted to sleep and this was seen as the only option becasue of the shows. it doesnt hurt mj one bit.


not really. i would think its pretty impossible to get an exact time unless the circumstances support it. generally i would think u would be looking at a TOD within so many hours. look at the medics they said within 20 mins and 1 hr when they got there. they may have a rough idea but i doubt u could ever prove it down to a certain time
Click to expand...

so elusive,

do you think Ratner will testify to that? and if MJ had this severe insomnia for 20 years why didn't he get real help for it? why didn't any of these 'so called' doctors refer him to a sleep specialist?
 
why do u keep askings questions that none of us have the answer to. u are starting to ruin this section like u did on kop board
 
StacyJ said:
Murray's team has said that Murray took all of the proper precautions. I am still trying to find out what precautions did Murray take? I have yet to hear of any precautionary measures he took
Click to expand...
The defense are very confused if they think that what Murray did was proper precautions. There was no heart monitor machine....the ambu bag was in the closet...there was no resuscitation equipment at all. Murray gave propofol in a home setting...he DIDN"T even know how to do CPR. That defense team is a stupid as Murray. Murray failed Michael miserably!!
 
xthunderx2 said:
The defense are very confused if they think that what Murray did was proper precautions. There was no heart monitor machine....the ambu bag was in the closet...there was no resuscitation equipment at all. Murray gave propofol in a home setting...he DIDN"T even know how to do CPR. That defense team is a stupid as Murray. Murray failed Michael miserably!!
Click to expand...

exactly... so how can they talk about precautionary measures?
 
Autumn II said:
Neil Ratner, the doctor who accompanied Michael on the HIStory tour, wouldn't talk to media at all, and to my knowledge, never has. CNN tried to talk to him (I saw it), but he fled into his house and said "no comment." Personally, and given the media-messes during the trial, I trust NO "sources said" reporting. Especially (but not limited to) CNN. During the trial CNN got info from tabloids, i.e. the "voodoo" craziness! Unless Ratner testifies under oath at Murray's trial, I'd put this in the "voodoo" category of stories. ("Sources close to Jackson" could be absolutely ANYBODY. Or nobody?)

@font-face { font-family: "Times"; }@font-face { font-family: "Cambria"; }p.MsoNormal, li.MsoNormal, div.MsoNormal { margin: 0in 0in 0.0001pt; font-size: 12pt; font-family: "Times New Roman"; }div.Section1 { page: Section1; } "Michael Jackson traveled with what amounted to a mini-clinic, complete with an IV pole and an anesthesiologist who medicated the insomniac singer, during his HIStory tour in the mid-90s, sources close to Jackson told CNN Thursday.

On Thursday, the California attorney general's office said that it is helping the Los Angeles Police Department in the death investigation.

The anesthesiologist who accompanied Jackson during the 82-date world tour in 1996 and 1997 was Dr. Neil Ratner, the sources said.

They said Ratner would keep medical equipment in his hotel room, which he used to monitor Jackson's vital signs when the singer was asleep or "under," as one source put it.

The doctor apparently said Jackson had trouble sleeping and that Ratner helped "take him down" and "bring him back up," according to the source.

Ratner confirmed to CNN that Jackson suffered from a sleep disorder, but refused to address any of the other allegations.


"It's really something I don't want to talk about right now," he said outside his Woodstock, New York, home Thursday.


Ratner was stripped of his license to practice medicine for three years in 2002 after he was found guilty of insurance fraud."



Sources: http://www.cnn.com/2009/SHOWBIZ/Music/07/03/jackson.wrap/index.html

http://askville.amazon.com/Neil-Ratner-drug-Michael-Jackson/AnswerViewer.do?requestId=54963460
Click to expand...

It's true that Ratner has never admitted to giving Michael propofol, but he's an anesthesiologist who accompanied him on the tour, and knowing what we now know, putting two and two together is easy.

BUT, it doesn't matter what other doctors provided the propofol in the past, or if Michael pleaded for the propofol...a medical doctor who takes a Hippocratic oath to "do no harm" to a patient is responsible. Murray had an obligation as a physician to say NO. And, that was the testimony from the coroner, Dr. Rogers--that the propofol was THERE in Michael's home makes his death a homicide.

So, the defense has an upward climb in coming up with a new defense theory Murray.
 
StacyJ;3200434 said:
I find that odd too. and the fact that Murray has no idea when his patient died demonstrates he wasn't watching him at all
Click to expand...

Well really now, how on earth could he admit to knowing a time of death when he insisted Michael be transported to UCLA? What would he say, Oh, he died at 1200 but ignore that and continue CPR? If he admitted Michael died at, say 1150, murray wouldn't have had 2 days to go off and concoct his stories to try and save his sorry self. I don't mean to sound flippant but I've seen this brought up many times and places and I don't understand it. I mean common sense and all... If I'm misunderstanding something obvious, I sit here ready to be enlightened.

But back to the propofol topic. I just came across this from 2009. Don't exactly know if I should copy the whole article but it's not too long I don't think.
Michael Jackson’s Death From Propofol
August 24th, 2009
Although none of the editors of InsideSurgery.com participated in his care, we have followed closely the news reports of his death and the developing story that physician-prescribed sedatives might have contributed to an overdose that caused a cardiorespiratory death.

Major news organizations are now reporting that the coroner is likely to rule Jackson’s death a homicide. The reported exact doses and schedule of the powerful sedatives prescribed to Jackson are being detailed.

The author of this post is a critical care physician who has wide experience with administering Valium, Ativan, and propofol to patients and who has received propofol as a patient. Some thoughts on the use of these drugs and the care that Jackson reportedly received is below:

Propofol

First and foremost, propofol (Diprivan) should never be given in a home setting: this is grossly outside of the scope of acceptable practice. This drug is a cardiac and respiratory depressant and should only be given by anesthesia and intensive care physicians with wide experience.

Propofol has a relatively short onset of duration and a short duration of effect – if the patient is drug naieve to it. That is, if you only see the drug when you have your colonscopy every five years, it works within seconds of onset and “goes away when it is turned off.”

However, it can and will build up in the tissues in patients who have received long infusions of it or shorter, frequent exposure to it and can potentiate additional doses.

Jackson’s doctor reportedly said that he injected Jackson and then left the room for a few minutes and when he returned, Jackson had stopped breathing. Patients should NEVER be left alone after being administered propofol, even for a few seconds.

Patients being given this drug must be placed on a heart monitor that detects heart rate and a blood pressure monitor of some type. It is not clear from reports if this was done by Dr. Murray

Jackson’s doctor claims he placed an oxygen saturation monitor on the patient. This device is a measure of oxygenation or “O2 saturation” only.

This type of monitor does not measure the respiratory status of a patient or how deeply and how fast a patient is breathing. It does not measure the patients partial pressure of carbon dioxide or PCO2, which is the important respiratory fvalue to monitor when giving propofol and “benzo’s”.

For example, it is possible to be dead and have a normal oxygen saturation for several minutes.

A physician who does not understand the above described limitations of monitoring is by definition not qualified to administer the drug.

When giving propofol to a non-intubated patient (i.e., without the breathing tube), the maximum initial dose I will use is 10 mgs. Dr. Murray administered 25 mgs after several doses of benzodiazepines (Ativan, Valium, and Versed), which will increase the heart and lung depression effect of propofol.

Patients sedated with propofol are not asleep (as Michael Jackson wished to be) and the use of propofol as a sleep inducer in the United States is outside the scope of standard care.

There is no reversal drug or antidote available to treat a propofol overdose, unlike Ativan, Valium, and Versed (which can be treated with the drug flumazenil.)

Patients who have respiratory depression with propofol need artificially controlled respirations by one of several methods.

A bag mask can be placed over the mouth and nose with air or oxygen forced into the lungs by squeezing it. Alternately, an endotracheal tube (breathing tube) or laryneal mask airway can be placed into the pharynx with air or oxygen delivered to the lungs.

It is not clear from reports if Dr. Murray had these items available when he administered the propofol, but if he did not it would be grossly negligent.

Benzodiazepines (Valium, Ativan, Versed)

Unlike propofol, these drugs are used as sleep inducers, but they are also strong sedatives that have the same respiratory and cardiac depressant effects as propofol.

Reports claim that Jackson was injected with these drugs. It is not clear if the injection was into a vein (intravenously) or into the muscle (intramuscularly or IM.)

Almost universally in the United States, benzodiazepines administered at home are given orally in pill form.

After Jackson was found to be in arrest, it is not clear if he was given flumazenil to reverse the effect of the Valium, Ativan, or Versed or if this was even available.

In medical settings, this reversal drug is typically available in case of overdose.

The dose and timing of the benzo’s given to Jackson is not inordinately high for an intensive care setting for a patient on a ventilator, but it is more than would be considered prudent in an outpatient, home setting.

Criminal Charges/Medical Malpractice

If accurate as reported, the administration of these drugs in this manner to Michael Jackson by Dr. Murray is widely deviant from standard of care. It may even be criminally negligent. However, although I am not an attorney or judge, it seems difficult to see how this would fit the charge of murder. It seems unlikely that Murray was intentionally giving Jackson these drugs to harm him.
http://insidesurgery.com/2009/08/michael-jacksons-death-from-propofol/

the bolded, blue section: I thought that was quite interesting. It's the first time I've read that it can build up in the tissues and potentiate additional doses, etc... If this is what happened and if murray didn't know this and continued to give his 'usual' doses I can see how he could have gotten into trouble.
And Michael had anesthetic levels of the drug in his system.
 
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