Murray Trial - October 13 - Day 12 - Discussion

Hi everyone,

sorry guys, my computer (and a lot of other stuff) are giving me a hard time today, couldn't post the recap earlier.
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Dr Kaimangar

cross by Flanagan

If a patient is not in his area of expertise, he would send him to another specialist.

If a patient patient has had a bad therapy but was insisting on reciving it, what would you do ? : Nk would refuse the care, try to understand the problem, make sure the patient understands, patient may need another specialist

Did CM have theses conversations with mj : i don't know, there were no records

what if a patient asks for unapprioate therapy ? you should try to understand why they are refusing an appropriate therapy, and what does the patient really needs, and send him to the appropriate doctor, make sure that they get the right care , would not give the patient a care that he thinks is inappropriate


CM gave propofol during 2 months, and MJ had no problem : I don't know, there are no records, how don't know if MJ had no problems

In the evaluation of the degree of deviation from standard of care , the end result doesn't matter.

Do you know what happened on june 25th ? : MJ was receiving inappropriate therapy, with inappropriate equipment, in a dehydrated patient, delay in calling 911, that resulted in MJ's death

valium + mizadolam +lorazepam+ 25 mg propofol was an inappropriate cocktail,

Can this coctail be the cause of MJ's death : absolutely, especially Propofol and lorazepa, in a dehydrated patient, whose vitals we don't know ( blood pressure, heart rate, medication, etc )because there are no records

Flanagan : you don't know, if Murray had that info : in medecine, we can not take care of patient if we don't document things. It allows us to follow the patient.

You prepare a record for every patient so that you can remeber, and other ppl can know what happened : that is not the only reason.

The fact that CM did not keep records means that you can not interpret what happened : no it means that he didn't have the info, you can't take care of a patient only from memory. It's a recipe for disaster

have you been with one patient for 9 hours : yes, sometimes longer . Keeps notes. Nurses keep notes. Needs to refer to the charts frequently to get a better picture. It's imperative to have charts.

You think there's no way CM remebered what he was doing : keeping records is imperative, it's standard of care, especially when you give such a powerful drug as propofol.

Not keeping the charts did not kill MJ : it's a combination of many factors that killed MJ. The ailure of chart is a contributing factor in this particular context

You consider lack of charting bad medecine : yes it is clerly bad medicine.

Propofol + lorazepam was the direct cause of M's death, yes and they were given in bad circumstances

Lorazepam + propofol : lorazepam increased the side effects of propofol: I can't anser that, only can say that can be a lethal combination in a patient that is not monitored. Doesn't want to comment on the effect of lorazepam and propofol : he's not phamacologist. Has an understanding, but is not an expert in pharmacology.

Would the level of propofol be lethal without the lorazepam : defers to a pharmacologist

You don't know how much of propofol was given based on a 2.6 level : seen in people who self injection who had levels between 1 and 6, but would like to refer to a pharmacology expert.

Have you reviwed the records of A Klein : yes

did you review treatments given by Klein for april may june : yes

did he give 6500 mg demerol : he treated MJ with demerol

did you see that when MJ was getting demerol he was also getting midazolam : yes

MJ had a demerol problem : can't answer the question

What is demerol : pain killer, narcotic

what is midazolam : sedative , so the patient is not aware of the procedure

Is 200 mg demerol a large dose : it's a signifant dose. Avoids using demerol, makes someone more hyper, excitable, creates more stimulation.

Basic injection is hypnotic : can create euphoria, can cause neuro exitory effects, can cause insomnia in certain people. Secondary cause of insomnia.

Did MJ had insomnia problems : yes, he clerly had

What type of insomnia ? : there was no type of effort done to determine that. Can not say, can only make suggestions, but perhaps anxiety, dependency to certain medication (demerol) . There was some indication that there were suggestions of secondary causes.

Did MJ have refractery insomnia : NK can not say that;

What is primary insomnia : when there is no secondry causes, when no other treatment works.

Did you read CM 2206 2007 medical records for MJ: yes they were scatterd records

There were other sleep mediactions in mj's house prescriped by other doctors : yes

He had several doctors precribing for insomnia : yes, Metzger, Klein, doesn't recall dr Adams

So several drs tried : yes

Have you ever had a patient that was not forthright in their history , how do you handle it : Yes, he tries to get information from patient and from other doctors.

If the patient doesn't sign the relaese , you dont get his medical records : yes, you can't get them

Then what do you do : ask the people who live with the patient, asks for a sleep log

Using Ambien without a proper evluation of insomnia is not right, but not a serious deviation

Enlarged prostate can cause insomnia : yes.

Would you check arms for needle marks : yes, it's part of physical exam;

Would you detect IM (intra muscular) demerol : : it's variable, you may see it in some individuals

you know MJ had demeraol : yes, doesnt remeber the fequency. CM should have known, from the people around MJ, MJ's behavior, slurred speech, from people who witnessed the change of behavior. Example : his drivers.

So CM, should have interviewed security : yes . If he had heard that MJ was acting differently, CM should have found out.

There are studies about propofol as a treatment for insmonia : These are just experimental , it is in no way is a standard of care.

Taiwan study : dates back to november 2010. Patients had been extensively evaluated, informed constent was obtained, they fasted for 8 hours, the study was done in a highly monitored setting, reciving propofol via an IV pump. 64 patients received propofol. The patient fell asleep better, have less sleep interruptions. No complications because they were highly monitored. It's very prelimanry experient, good results. It has no clinical applicability, the Dr that conducted the study stated that there was aneed for further study.

Why is it incomprehensible to use propofol for insomnia : it was astudy, in a highly monitered settings. It is incomprehensible and inacceptable , especially with no monitoring and home setting.

25 mg propofol is a very low dose ? : yes.

You wouldn't expect problems with such a small dose : it depends on the patient : if the patient is dehydrated, had other medication (ie lorazepam), low blood pressure , there can be a problem that can lead to respiratory depression.

Lorazepam ; is not fda approved for primary insomnia, especially IV. Lorazepam in oral form can be used if cause of insomnia is anxiety, for a very short period of time: 3 to 4 weeks.

What is the diffrence in IV in oral : Lorazepam creates a great dependancy. Oral form is appropriate for short period of time. Iv is anappropriate, because monitoring is necessary, you get a larger dose when given IV. Even with monitoring, it is not FDA approved for insomnia.

Was lorazepam appropriate with anxiety due to an upcoming event (this is it) : what should have been done is to have psychological or psychiatric help. NK would not have used it in this case

EDIT : NK said he wouldn't have cancelled the event, but would have tried to find a solution to the anxiety

break
 
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paul white works for this guy on his journal.

takes 50-60 hrs a week reviewing manuscripts for his journal. editor on the UK and japanese board of anthetists journal.

apologies if spelling goes off. going to bed at 4am is catching up on me
 
Dr Shaeffer...coughed all over the microphone, and said he needed to look at his CV as forgotten all the boards of journals he's been on....going through his various studies and schools.
 
This guy's Ivy League all the way. Princeton, Columbia, UPenn, Stanford. Wow.

I'm waiting for the cross lol.
 
I actually started crying when I realized that I was thinking that this guy is like MJ of anesthesiologists.
I usually distance myself and forget what this case is really about.
 
defence claimed shafer was under/worked for white in their opening statement. thats false. hes known white since 1981. been friends ever since.

whats the dosing guidlines for diprivan.. going through the history of it and previous issues with midaz back in the 1980s so the FDA were very careful about it. the fda wanted to know thee safest rate. shaffer did all the testing of this . he bascially created the guidlines back in 91.

the infusion rate (the rate it drips in)
 
showing the packaging from a diprivan bottle. the paper you get inside with all the do's and dont's. shaffer contributed to that.showing a graph he created for ICU sedation. describing the difference between diprivan and profopol.
 
Shaefer is basically the guy who wrote the instructions or had some input on writing the instructions for using Diprivan. Hot damn. Doesn't get any better than this, imo.
 
special goverment employee of the FDA worked with them for 20 years. 2002-6 member of a drug advisory commitee on anestheology FDA would come to them for guidence on new drugs. was the chairman at one point aswell for 2 years. job as chair included working wiht FDA on issues about anesthetics
 
Steven Shaffer explains what is meant by Pharmacokinetics, it's to do with Drugs in motion, when drug is given to paitent, it goes through several processes. Simply defined as what the body does to the drug. Pharmacokinetics specifically direct to the fate of the molecule of the body.

Shaffer has 19 papers specific to Propofol.
 
Thank god for the updates here. I'm not able to watch the trial today
 
he's published 19 papers specific to Propofol pharmo-kinetic...first paper was published with Paul White and his wife
 
pharma co connetics is about drugs in motion. you give a drug to a paitent it goes through several motions. goes into the paitent and gets diluted by the blood. the blood is in motion so takes the drug everywhere in the body including the brain and the liver. what happens to the molecules that end up in the liver etc what happens to the pieces after the liver chews it up.it can then travel to the kidneys out in the urine etc. its about drug movement in the body. has had 19 papers on it published the 19 papers were about diprivan. hes released papers with white aswell.
 
I like the way the Dr. is explaining how the drug gets into the bloodstream and travels and all that jazz. I'm not a science person but I am getting this so far. He's good at breaking it down into elementary language so hopefully the jury won't get too confused or go to sleep. haha
 
lunch break

and it's over for the day due to scheduling issues...back on Monday
 
I like the way the Dr. is explaining how the drug gets into the bloodstream and travels and all that jazz. I'm not a science person but I am getting this so far. He's good at breaking it down into elementary language so hopefully the jury won't get too confused or go to sleep. haha

Yes, and he's also engaging the jury by talking directly to them. That way they're more likely to pay attention and keep focused.
 
Wow, court's over already due to issues with witness scheduling! Remember no court tomorrow either so back on Monday.
 
stipulation coming from walgren. previous exibit 166 finger prints saline IV bag 4 prints were on it but no ID was made from the prints

is that the iv bag that had the diprivan bottle in it? or the saline bag that was still hung up
 
Judge Pastor asks Walgren… "Can I do my thing now?" :lol:

Judge says to the Jury… "You can repeat after me as you now them by now"

Love Judge Pastor :lol:
 
how can there be witness scheudule problem when the witness is there and expected to be on the stand for hours?
 
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