lemon662
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Popescu:
I was under the impression that perhaps not only could Propofol cause pain to the vein if not mixed w/ Lidocaine but that it might actually cause inflammation or damage to the vein (eg: phlebitis)...but I was just reading the package insert on Propofol from the drug company (link below) and it seems that phlebitis is a very rare side effect.
I did find an interesting tidbit from this same document, indicating that if one is diluting Propofol, they should only ever be using an IV solution of D5W (5% dextrose IV solution)....AND if administering using a Y-type administration set, of the compatible IV solutions listed, normal saline is not one of them. Normal Saline is generally 0.9% and I assume that's what Murray was using. I guess if we looked up the records from Sea Coast medical supplies, it would specify the Normal Saline he had ordered/was using.....
If you look at this info from the package insert, compatible IV solutions for Y-site administration that contain Normal Saline are a lesser concentration (0.2 % and 0.45% sodium chloride). But I believe Murray was using just straight Normal Saline (sodium chloride) of 0.9%.
Compatibility and Stability: DIPRIVAN Injectable Emulsion should not be mixed with other therapeutic agents prior to administration.
Dilution Prior to Administration: DIPRIVAN Injectable Emulsion is provided as a ready to use formulation. However, should dilution be necessary, it
should only be diluted with 5% Dextrose Injection, USP, and it should not be diluted to a concentration less than 2 mg/mL because it is an emulsion. In diluted
form it has been shown to be more stable when in contact with glass than with plastic (95% potency after 2 hours of running infusion in plastic).
Administration with Other Fluids: Compatibility of DIPRIVAN Injectable Emulsion with the coadministration of blood/serum/plasma has not been established.
(See WARNINGS.) When administered using a y-type infusion set, DIPRIVAN Injectable Emulsion has been shown to be compatible with the following
intravenous fluids.
– 5% Dextrose Injection, USP
– Lactated Ringers Injection, USP
– Lactated Ringers and 5% Dextrose Injection
– 5% Dextrose and 0.45% Sodium Chloride Injection, USP
– 5% Dextrose and 0.2% Sodium Chloride Injection, USP
The above excerpt comes from bottom left of page 4 of this document:
http://www1.astrazeneca-us.com/pi/diprivan.pdf
I was under the impression that perhaps not only could Propofol cause pain to the vein if not mixed w/ Lidocaine but that it might actually cause inflammation or damage to the vein (eg: phlebitis)...but I was just reading the package insert on Propofol from the drug company (link below) and it seems that phlebitis is a very rare side effect.
I did find an interesting tidbit from this same document, indicating that if one is diluting Propofol, they should only ever be using an IV solution of D5W (5% dextrose IV solution)....AND if administering using a Y-type administration set, of the compatible IV solutions listed, normal saline is not one of them. Normal Saline is generally 0.9% and I assume that's what Murray was using. I guess if we looked up the records from Sea Coast medical supplies, it would specify the Normal Saline he had ordered/was using.....
If you look at this info from the package insert, compatible IV solutions for Y-site administration that contain Normal Saline are a lesser concentration (0.2 % and 0.45% sodium chloride). But I believe Murray was using just straight Normal Saline (sodium chloride) of 0.9%.
Compatibility and Stability: DIPRIVAN Injectable Emulsion should not be mixed with other therapeutic agents prior to administration.
Dilution Prior to Administration: DIPRIVAN Injectable Emulsion is provided as a ready to use formulation. However, should dilution be necessary, it
should only be diluted with 5% Dextrose Injection, USP, and it should not be diluted to a concentration less than 2 mg/mL because it is an emulsion. In diluted
form it has been shown to be more stable when in contact with glass than with plastic (95% potency after 2 hours of running infusion in plastic).
Administration with Other Fluids: Compatibility of DIPRIVAN Injectable Emulsion with the coadministration of blood/serum/plasma has not been established.
(See WARNINGS.) When administered using a y-type infusion set, DIPRIVAN Injectable Emulsion has been shown to be compatible with the following
intravenous fluids.
– 5% Dextrose Injection, USP
– Lactated Ringers Injection, USP
– Lactated Ringers and 5% Dextrose Injection
– 5% Dextrose and 0.45% Sodium Chloride Injection, USP
– 5% Dextrose and 0.2% Sodium Chloride Injection, USP
The above excerpt comes from bottom left of page 4 of this document:
http://www1.astrazeneca-us.com/pi/diprivan.pdf